{"id":7836,"date":"2023-05-22T13:36:53","date_gmt":"2023-05-22T11:36:53","guid":{"rendered":"https:\/\/efvr1v90ll.wpdns.site\/bez-katehorii\/endosafe-bacterial-endotoxin-testing-systems\/"},"modified":"2023-06-29T15:59:00","modified_gmt":"2023-06-29T12:59:00","slug":"endosafe-bacterial-endotoxin-testing-systems","status":"publish","type":"post","link":"https:\/\/alsi.ua\/en\/bacterial-endotoxin-testing-systems\/endosafe-bacterial-endotoxin-testing-systems\/","title":{"rendered":"Endosafe\u00ae bacterial endotoxin testing systems"},"content":{"rendered":"<p>The Charles River Endosafe\u00ae Series of Bacterial Endotoxin Detection Systems are designed for rapid quantitative endotoxin testing using unique, state-of-the-art cartridge technology. Today, more than 6,000 Charles River cartridge systems have been implemented around the world, and Endosafe\u00ae technologies are used by such global giants as Baxter, Pfizer, Roche, AstraZeneca, etc.<\/p>\n<p>The cartridge technology for bacterial endotoxin control is based on the pharmacopoeial kinetic chromogenic method in a modification using disposable polystyrene cartridges filled with pre-calibrated reagents. The cartridges contain repeatable channels for sample introduction and positive control and are characterized by a sensitivity range of 0.005 to 50 EU\/ml. The use of LAL cartridges with Endosafe\u00ae systems reduces test time to 15 minutes, simplifying product quality analysis, increasing test efficiency, and providing fast, accurate, reproducible results. Endosafe\u00ae cartridges are licensed by the U.S. FDA and recommended for use in accordance with USP BET&lt;85&gt; and EP BET&lt;2.6.14&gt;.<\/p>\n<p>Cartridge technology has a number of advantages over traditional methods, including short test times, quantitative reproducible results, and a simple test protocol. In addition, the cartridge technology uses only 1\/20 of the raw materials required for a traditional test, significantly reduces labor-intensive test preparation, and does not require special training and staff training.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr style=\"background-color: #96c8e7;\">\n<td style=\"vertical-align: top; border-style: solid; text-align: center;\" width=\"132\"><strong>Method.<\/strong><\/td>\n<td style=\"vertical-align: top; border-style: solid; text-align: center;\" width=\"163\"><strong>Test duration<\/strong><\/td>\n<td style=\"vertical-align: top; border-style: solid; text-align: center;\" width=\"201\"><strong>Main advantages<\/strong><\/td>\n<td style=\"vertical-align: top; border-style: solid; text-align: center;\" width=\"311\"><strong>The main disadvantages<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"132\"><strong>Gel thrombus<\/strong><\/td>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"163\">60 min + 30 min test preparation<\/td>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"201\">Does not require special equipment, relatively low test cost<\/td>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"311\">Subjective qualitative results, dependence on the &#8220;human factor,&#8221; lengthy test administration, the need for a large number of reagents and consumables<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"132\"><strong>Traditional kinetic test<\/strong><\/td>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"163\">60 min + 30 min test preparation<\/td>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"201\">Accurate quantitative objective results<\/td>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"311\">Lengthy testing, complex testing protocol, need for special equipment<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"132\"><strong>Cartridge technology<\/strong><\/td>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"163\">15 min + 2 min test preparation<\/td>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"201\">Reproducible quantitative objective results, significantly shorter test time, simple method protocol<\/td>\n<td style=\"text-align: left; vertical-align: top; border-style: solid;\" width=\"311\">The need for special equipment<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>The Charles River Endosafe\u00ae series of endotoxin testing systems includes three types of systems with different configurations: the nexgen PTS portable system that can test a single sample for up to 15 minutes, the nexgen MCS modular system that can test up to five samples in parallel, and the Nexus robotic system with a test capacity of up to 60 samples in 15 minutes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Charles River Endosafe\u00ae Series of Bacterial Endotoxin Detection Systems [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":7011,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[874],"tags":[],"class_list":["post-7836","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bacterial-endotoxin-testing-systems"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Endosafe\u00ae bacterial endotoxin testing systems &#8226; 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